Peptide Engineering
A man running at first light
Energy

Metabolic Energy

Energy isn't only made — it's burned. How cleanly your metabolism runs decides whether the food you eat becomes usable energy or just sits there as a tax. The good news: unlike most things, you can physically build a bigger, cleaner engine.

Julian Caraulani · June 30, 2026 · 7 min read

Once you're sleeping, the next lever is how cleanly your body makes and burns fuel. This is the one most men get backwards — they chase a stimulant to feel energetic when the real problem is an engine that's small, inflamed, or riding a blood-sugar rollercoaster. All three are fixable, and one of them you can literally grow.

The engine

You can grow more mitochondria

Easy, conversational, nose-breathing cardio — zone 2, where you can still hold a conversation — done ~3× a week drives mitochondrial biogenesis: your muscles build more mitochondria and more of the enzymes that burn fat for fuel. This isn't new; we've known it since 1967. 1 It's why Peter Attia treats zone-2 as the base of the entire exercise pyramid — the slow, unglamorous work that builds the engine everything else runs on. 2

A man running at dawn
Zone-2 isn’t punishment cardio. It’s the slow work that builds the engine.
The tax

Why extra weight costs you energy

Excess body fat isn't inert storage — it's metabolically active tissue that pumps out low-grade inflammation, and inflammation taxes every cell's ability to make and spend energy cleanly. Getting lean isn't just about looking better; it lifts a chronic, invisible load off the whole system. You don't notice it until it's gone and you wonder where the extra gear came from.

The fuel

The 3pm crash is a blood-sugar problem

That mid-afternoon slump that feels like an energy problem is usually a glucose one. Refined-carb meals spike blood sugar and then drop it, and the crash reads as fatigue. Protein-forward meals flatten the curve — steadier glucose, steadier energy. 3 If you want to actually see it, a continuous glucose monitor for a month is the cheapest education in metabolism you can buy.

Worth paying for here: creatine (the most evidence-backed supplement that exists — and it helps the brain, not just the gym), electrolytes, and a glucose monitor for a month to find your own crash foods. Everything else is training and food.

Build the metabolic stack tuned to your goal and your numbers.

Engineer your protocol →

References

  1. 1Holloszy, J.O. — "Biochemical adaptations in muscle: effects of exercise on mitochondrial oxygen uptake and respiratory enzyme activity." Journal of Biological Chemistry, 242(9), 1967.
  2. 2San-Millán, I. & Brooks, G.A. — zone-2 intensity, lactate clearance and mitochondrial / fat-oxidation adaptation. Sports Medicine, 2018.
  3. 3Zeevi, D. et al. — "Personalized Nutrition by Prediction of Glycemic Responses." Cell, 163(5), 2015.
Engineer the rest.